Myeloperoxidase ist ein Gen, das durch das Symbol MPO kodiert wird. Es ist auch bekannt als MPO. Myeloperoxidase hat eine Masse von 83.87kDa, eine Aminosäurelänge von 745, und ist an Myeloperoxidase deficiency beteiligt.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Entrez Zusammenfassung
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils.
Rolle bei Krankheiten
Myeloperoxidase deficiency: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
Sequenzähnlichkeiten
Belongs to the peroxidase family. XPO subfamily.
