Macrophage inflammatory protein 5 ist ein Gen, das durch das Symbol CCL15 kodiert wird. Im Allgemeinen auch bezeichnet als: C-C motif chemokine 15; Chemokine CC-2; HCC-2; Leukotactin-1; LKN-1; MIP-1 delta; MIP-5; Mrp-2b; NCC-3; Small-inducible cytokine A15; CCL15; MIP5; NCC3; SCYA15. Macrophage inflammatory protein 5 hat eine Masse von 12.25kDa und eine Aminosäurelänge von 113.
Wir bieten 1 Macrophage inflammatory protein 5 ELISA-Kits zum qualitativen oder quantitativen Nachweis von Macrophage inflammatory protein 5 von Human proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Entrez Zusammenfassung
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14).
Gewebespezifität
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
Sequenzähnlichkeiten
Belongs to the intercrine beta (chemokine CC) family.
