LBP ist ein Gen, das durch das Symbol LBP kodiert wird. Es ist auch bekannt als Lipopolysaccharide-binding protein. LBP hat eine Masse von 53.38kDa und eine Aminosäurelänge von 481.
Wir bieten 13 LBP ELISA-Kits zum qualitativen oder quantitativen Nachweis von LBP von Human, Maus, Ratte, Rind, Schwein und Affe proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Entrez Zusammenfassung
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).
Gewebespezifität
Detected in blood serum (at protein level).
Sequenzähnlichkeiten
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Zellort
Secreted. Cytoplasmic granule membrane.
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
