IL-17a ist ein Gen, das durch das Symbol IL17A kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; IL17A; CTLA8; IL17. IL-17a hat eine Masse von 17.5kDa und eine Aminosäurelänge von 155.
Wir bieten 40 IL-17a ELISA-Kits zum qualitativen oder quantitativen Nachweis von IL-17a von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Schaf, Hund, Goat, Meerschweinchen, Pferd und Primaten proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Entrez Zusammenfassung
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Gewebespezifität
Restricted to activated memory T-cells.
Sequenzähnlichkeiten
Belongs to the IL-17 family.
Posttranslationale Modifikation
Found both in glycosylated and nonglycosylated forms.
