HGF ist ein Gen, das durch das Symbol HGF kodiert wird. Im Allgemeinen auch bezeichnet als: Hepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF; HPTA. HGF hat eine Masse von 83.13kDa, eine Aminosäurelänge von 728, und ist an Deafness, autosomal recessive, 39 beteiligt.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Entrez Zusammenfassung
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.
Rolle bei Krankheiten
Deafness, autosomal recessive, 39: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family. Plasminogen subfamily.
