Follistatin ist ein Gen, das durch das Symbol FST kodiert wird. Andere Namen sind: FS; Activin-binding protein; FST. Follistatin hat eine Masse von 38.01kDa und eine Aminosäurelänge von 344.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Entrez Zusammenfassung
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Gewebespezifität
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
