Fatty Acid Synthase ist ein Gen, das durch das Symbol FASN kodiert wird. Andere Namen sind: FASN; FAS. Fatty Acid Synthase hat eine Masse von 273.43kDa und eine Aminosäurelänge von 2511.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Entrez Zusammenfassung
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Gewebespezifität
Ubiquitous. Prominent expression in brain, lung, and liver.
Zellort
Cytoplasm. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
