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Cystatin C Assays

16 Products

Cystatin C ist ein Gen, das durch das Symbol CST3 kodiert wird. Andere Namen sind: Cystatin-C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin; CST3. Cystatin C hat eine Masse von 15.8kDa, eine Aminosäurelänge von 146, und ist an folgenden Krankheiten beteiligt: Amyloidosis 6; Macular degeneration, age-related, 11.

Wir bieten 16 Cystatin C ELISA-Kits zum qualitativen oder quantitativen Nachweis von Cystatin C von Human, Maus, Ratte, Schwein und Affe proben.

Gen- und Proteininformationen

UniProt Zusammenfassung
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Entrez Zusammenfassung
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.
Gewebespezifität
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
Rolle bei Krankheiten
Amyloidosis 6: A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.

Macular degeneration, age-related, 11: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequenzähnlichkeiten
Belongs to the cystatin family.
Posttranslationale Modifikation
The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.
Zellort
Secreted.
Standard Curve - Mouse Cystatin C ELISA Kit (A76420) - Antibodies.com
Standard Curve - Monkey Cystatin C ELISA Kit (A74378) - Antibodies.com
Standard Curve - Human Cystatin C ELISA Kit (A313507) - Antibodies.com
Produkt anzeigen90-Minuten-ELISA
Standard Curve - Rat Cystatin C ELISA Kit (A1860) - Antibodies.com
Standard Curve - Rat Cystatin C ELISA Kit (A77962) - Antibodies.com
Standard Curve - Human Cystatin C ELISA Kit (A1859) - Antibodies.com
Standard Curve - Rat Cystatin C ELISA Kit (A303799) - Antibodies.com
Standard Curve - Porcine Cystatin C ELISA Kit (A3172) - Antibodies.com
Standard Curve - Porcine Cystatin C ELISA Kit (A74379) - Antibodies.com
Standard Curve - Human Cystatin C ELISA Kit (A77961) - Antibodies.com
Standard Curve - Mouse Cystatin C ELISA Kit (A1861) - Antibodies.com
Standard Curve - Human Cystatin C ELISA Kit (Lum-8325) - Antibodies.com
(3)
Standard Curve - Human Cystatin C ELISA Kit (OK-0325) - Antibodies.com
(3)
Standard Curve - Human Cystatin C ELISA Kit (EK1114) - Antibodies.com
Standard Curve - Human Cystatin C ELISA Kit (BEK1039) - Antibodies.com
Standard Curve - Mouse Cystatin C ELISA Kit (BEK1040) - Antibodies.com

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