CEACAM5 ist ein Gen, das durch das Symbol CEACAM5 kodiert wird. Andere Namen sind: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100. CEACAM5 hat eine Masse von 76.8kDa und eine Aminosäurelänge von 702.
Wir bieten 5 CEACAM5 ELISA-Kits zum qualitativen oder quantitativen Nachweis von CEACAM5 von Human und Maus proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Entrez Zusammenfassung
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. CEA family.
Posttranslationale Modifikation
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Zellort
Cell membrane. Apical cell membrane. Cell surface.
Localized to the apical glycocalyx surface.
