CD62P ist ein Gen, das durch das Symbol SELP kodiert wird. Andere Namen sind: P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; SELP; GMRP; GRMP. CD62P hat eine Masse von 90.83kDa, eine Aminosäurelänge von 830, und ist an Ischemic stroke beteiligt.
Wir bieten 11 CD62P ELISA-Kits zum qualitativen oder quantitativen Nachweis von CD62P von Human, Maus, Ratte, Schwein und Kaninchen proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
Entrez Zusammenfassung
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Gewebespezifität
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Rolle bei Krankheiten
Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequenzähnlichkeiten
Belongs to the selectin/LECAM family.
