CD147 ist ein Gen, das durch das Symbol BSG kodiert wird. Andere Namen sind: Basigin; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; BSG. CD147 hat eine Masse von 42.2kDa und eine Aminosäurelänge von 385.
Wir bieten 8 CD147 ELISA-Kits zum qualitativen oder quantitativen Nachweis von CD147 von Human, Maus, Ratte und Kaninchen proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Entrez Zusammenfassung
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in erythrocytes (at protein level) (PubMed:28409866, PubMed:26195724). Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Posttranslationale Modifikation
N-glycosylated.
Zellort
Cell membrane. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity).
Biotechnologische Verwendung
Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, neutralizing antibodies are capable of inhibiting merozoite invasion of host erythrocytes.
