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Bcl-2 Assays

13 Products

Bcl-2 ist ein Gen, das durch das Symbol BCL2 kodiert wird. Es ist auch bekannt als Apoptosis regulator BCL2. Bcl-2 hat eine Masse von 26.27kDa und eine Aminosäurelänge von 239.

Wir bieten 13 Bcl-2 ELISA-Kits zum qualitativen oder quantitativen Nachweis von Bcl-2 von Human, Maus, Ratte, Rind, Kaninchen und Meerschweinchen proben.

Gen- und Proteininformationen

UniProt Zusammenfassung
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Entrez Zusammenfassung
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed in a variety of tissues.
Sequenzähnlichkeiten
Belongs to the Bcl-2 family.
Posttranslationale Modifikation
Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Zellort
Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Standard Curve - Human Bcl-2 ELISA Kit (A76197) - Antibodies.com
Standard Curve - Rat Bcl-2 ELISA Kit (A77742) - Antibodies.com
Standard Curve - Human Bcl-2 ELISA Kit (A1842) - Antibodies.com
Standard Curve - Rabbit Bcl-2 ELISA Kit (A74343) - Antibodies.com
Standard Curve - Guinea Pig Bcl-2 ELISA Kit (A73898) - Antibodies.com
Standard Curve - Bovine Bcl-2 ELISA Kit (A7238) - Antibodies.com
Standard Curve - Mouse Bcl-2 ELISA Kit (A1844) - Antibodies.com
Standard Curve - Mouse Bcl-2 ELISA Kit (A77743) - Antibodies.com
Standard Curve - Rat Bcl-2 ELISA Kit (A1843) - Antibodies.com
Western Blot - BCL-2 Cell Based ELISA Kit (CB5068) - Antibodies.com
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Western Blot - BCL-2 (phospho Thr56) Cell Based ELISA Kit (CBP1506) - Antibodies.com
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Western Blot - BCL-2 (phospho Ser70) Cell Based ELISA Kit (CBP1505) - Antibodies.com
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Protocol Diagram - BCL-2 (phospho Ser87) Cell Based ELISA Kit (CBP1142) - Antibodies.com
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