Adenosine Receptor A2a ist ein Gen, das durch das Symbol ADORA2A kodiert wird. Andere Namen sind: ADORA2A; ADORA2. Adenosine Receptor A2a hat eine Masse von 44.71kDa und eine Aminosäurelänge von 412.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
Posttranslationale Modifikation
Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
Zellort
Cell membrane.
Colocalizes with GAS2L2 at neuronal processes.
