Anti-PGP9.5 Antibody [BH7] (A279839)

Anti-PGP9.5 Antibody [BH7]

Mouse monoclonal [BH7] antibody to PGP9.5.

This antibody recognises protein gene product 9.5 (PGP9.5) also known as ubiquitin C terminal hydrolase 1 (UCH-L1). UCH-L1 is a thiol protease that recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. This protein is closely related to UCH-L3 and both are thought to recycle ubiquitin to maintain pools of monomeric ubiquitin necessary for proteolysis. UCH-L1 is expressed in neurons and cells of the diffuse neuroendocrine system and their tumours.UCH-L1 and UCH-L3 have been shown to have separate and overlapping functions in the maintanence of neurons of the gracile tract, nucleus tractus solitarius (NTS) and area postrema.

WB, IF

IF: 1:500, WB: 1:5,000

Human, Mammals, Mouse, Rat, Bovine

Recombinant full length human PGP9.5 purified from E.coli.

Mouse

Monoclonal

BH7

IgG1

Protein G affinity chromatography of tissue culture supernatant.

Approximately 24 kDa in rat hippocampal lysate

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.03% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human protein gene product 9.5 monoclonal antibody, clone BH7 recognizes protein gene product 9.5 (PGP9.5) also known as ubiquitin C terminal hydrolase 1 (UCH-L1). UCH-L1 is a thiol protease that recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. This protein is closely related to UCH-L3 and both are thought to recycle ubiquitin to maintain pools of monomeric ubiquitin necessary for proteolysis. UCH-L1 is expressed in neurons and cells of the diffuse neuroendocrine system and their tumours.UCH-L1 and UCH-L3 have been shown to have separate and overlapping functions in the maintanence of neurons of the gracile tract, nucleus tractus solitarius (NTS) and area postrema (Kurihara et al. 2001) .

Neuron cytoplasmic protein 9.5, PGP 9.5, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, UCH-L1, UCHL1