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Rekombinant Anti-Perforin Antikörper [PRF1/8662R] (A315501)

$765

Monoklonal [PRF1/8662R] Kaninchen Antikörper gegen Perforin für IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-Perforin Antibody [PRF1/8662R]
Beschreibung
Recombinant rabbit monoclonal [PRF1/8662R] antibody to Perforin.
Spezifität
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Anwendungen
IHC-P
Positivkontrolle
HDLM-2 cells. Human spleen.
Verdünnungen
IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant human Perforin-1 protein fragment (around Amino Acids 413-552). The exact sequence is proprietary.
Wirt
Rabbit
Klonalität
Monoclonal
Klon
PRF1/8662R
Isotyp
IgG
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
75 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
Cytolysin, FLH2, HPLH2, Lymphocyte pore-forming protein, P1, Perforin 1, perforin 1 (pore forming protein), Perforin-1, PERF_HUMAN, PFP, PGFL, PIGF, PIGF-2, PLGF, Pore forming protein, prf1, SHGC-10760
Isotyp-Kontrollantikörper
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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