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Anti-PD-L1 Antikörper [29E.2A3] (A279155)

$375

Monoklonal [29E.2A3] Maus Antikörper gegen PD-L1 für Flow Cytometry, IHC-Fr und Functional Assays.

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Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-PD-L1 Antibody [29E.2A3]
Beschreibung
Mouse monoclonal [29E.2A3] antibody to PD-L1.
Spezifität
This antibody recognises human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Anwendungen
Flow Cytometry, IHC-Fr, Functional Assays
Reaktivität
Human, Primate
Immunogen
Full length human CD274.
Wirt
Mouse
Klonalität
Monoclonal
Klon
29E.2A3
Isotyp
IgG2b
Konjugat

Unconjugated

Reinigung
Protein A affinity chromatography of tissue culture supernatant.
Konzentration
1 mg/ml
Reinheit
>95% (by SDS-PAGE).
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Lagerung
Store undiluted at 4°C. Do not freeze!
Allgemeine Hinweise
Mouse anti Human CD274 antibody, clone 29E.2A3 detects human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Synonyme
B7 H, B7 H1, B7 homolog 1, B7-H1, B7H, B7H1, CD 274, CD274, CD274 antigen, CD274 molecule, MGC142294, MGC142296, OTTHUMP00000021029, PD L1, PD1L1_HUMAN, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL 1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, RGD1566211
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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