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Anti-PAI1 Antikörper (A283160)

$645

Polyklonal Kaninchen Antikörper gegen PAI1 für WB, ELISA und IHC-P.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-PAI1 Antibody - BSA and Azide free
Beschreibung
Rabbit polyclonal antibody to PAI1.
Spezifität
This antibody recognises human PAI-1, also known as plasminogen activator inhibitor-1 or SERPINE1. PAI-1 is a ~45 kDa serine protease inhibitor and member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis.Mutations of the SERPINE1 gene are associated with Plasminogen activator inhibitor-1 deficiency (PAI-1D), a condition characterized by episodes of severe hemorrhage. Heterozygous carriers of the mutation do not display the same phenotype, instead demonstrate longer teleomere length, lower incidence of diabetes and increased longevity. Increased levels of PAI-1 are associated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity, and can be induced by obesity related factors including insulin, glucose and very-low-density lipoprotein.
Anwendungen
WB, ELISA, IHC-P
Verdünnungen
ELISA: 0.5 - 2 µg/ml, WB: 0.1 - 0.2 µg/ml
Reaktivität
Human
Immunogen
Recombinant human PAI-1.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat

Unconjugated

Konzentration
1 mg/ml after reconstitution.
Produktform
Lyophilized
Rekonstitution
Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Formulierung
Supplied in Phosphate Buffered Saline.
Lagerung
Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Allgemeine Hinweise
Rabbit anti Human PAI-1 antibody recognises human PAI-1, also known as plasminogen activator inhibitor-1 or SERPINE1. PAI-1 is a ~45 kDa serine protease inhibitor and member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis.Mutations of the SERPINE1 gene are associated with Plasminogen activator inhibitor-1 deficiency (PAI-1D), a condition characterized by episodes of severe hemorrhage (Saes et al. 2019). Heterozygous carriers of the mutation do not display the same phenotype, instead demonstrate longer teleomere length, lower incidence of diabetes and increased longevity (Khan et al. 2017).Increased levels of PAI-1 are associated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity, and can be induced by obesity related factors including insulin, glucose and very-low-density lipoprotein (Altalhi et al. 2021).
Synonyme
Clade E, Endothelial plasminogen activator inhibitor, Nexin, PAI, PAI 1, PAI-1, PAI1_HUMAN, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator inhibitor type 1, Serine (or cysteine) proteinase inhibitor, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpine 1, SERPINE1
Isotyp-Kontrollantikörper
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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