Recombinant Anti-p63 Antibody [P40/7302R] - BSA and Azide free (A316832)

Anti-p63 Antibody [P40/7302R] - BSA and Azide free

Recombinant rabbit monoclonal [P40/7302R] antibody to p63.

p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

HEK293, MDA-MB453 or MCF7 cells. Human prostate, lung or bladder squamous cell carcinoma tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human TP63 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

P40/7302R

kappa

Protein A chromatography.

1 mg/ml

63 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, KET, p40, p51, P73H, P73L, TP63, TP73L, Transformation-related protein 63, Tumor protein 63, Tumor protein p73-like