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Anti-p27 KIP 1 Antikörper [SX53G8] (CF® 488) (A251119)

Dieses Produkt wurde eingestellt.

Anti-p27 KIP 1 Antikörper [SX53G8] (CF® 488) (A251119) wurde eingestellt und ist nicht mehr verfügbar.

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Produktname
Anti-p27 KIP 1 Antibody [SX53G8] (CF® 488)
Beschreibung
Mouse monoclonal [SX53G8] antibody to p27 KIP 1 (CF® 488).
Spezifität
This antibody recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.
Anwendungen
Flow Cytometry, IF
Verdünnungen
Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100
Reaktivität
Human, Mouse, Rat, Monkey
Immunogen
Purified GST-p27 fusion protein of human origin.
Wirt
Mouse
Klonalität
Monoclonal
Klon
SX53G8
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

CF® 488

Excitation: 490nm, Emission: 515nm

Reinigung
Protein A/G chromatography.
Konzentration
100 µg/ml
Molekulargewicht
25-26 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Store at 4-8°C. Antibody is stable for 24 months.
Synonyme
AA408329, AI843786, Cdki1b, CDKN 1B, CDKN 4, CDKN1B, CDKN4, CDN1B_HUMAN, Cyclin Dependent Kinase Inhibitor 1B, Cyclin dependent kinase inhibitor p27, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor 1B (p27, Kip1), Cyclin-dependent kinase inhibitor p27, Cyclin-dependent kinase inhibitor p27 Kip1, KIP 1, KIP1, MEN1B, MEN4, OTTHUMP00000195098, OTTHUMP00000195099, p27, p27 Kip1, P27-like cyclin-dependent kinase inhibitor, p27Kip1
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.
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