Anti-p21 Antibody [CIP1/823 + DCS-60.2] (A248088)

Anti-p21 Antibody [CIP1/823 + DCS-60.2]

Mouse monoclonal [CIP1/823 + DCS-60.2] antibody to p21.

This antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdks and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 2-4 µg/ml

Human

This antibody does not cross react with Mouse or Rat.

Clone CIP1/823: Recombinant full-length human CDKN1A protein. Clone DCS-60.2: Recombinant human p21 protein.

Mouse

Monoclonal

CIP1/823 + DCS-60.2

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

21 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-p21 Antibody [CIP1/823 + DCS-60.2] - BSA and Azide free (A251271).

CAP20, CDK-interacting protein 1, CDKN1, CDKN1A, CIP1, Cyclin-dependent kinase inhibitor 1, MDA-6, MDA6, Melanoma differentiation-associated protein 6, PIC1, SDI1, WAF1