Anti-NME2 Antibody [NME2/4160] (A315396)

Anti-NME2 Antibody [NME2/4160]

Mouse monoclonal [NME2/4160] antibody to NME2.

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor.

WB, IHC-P

MCF-7, A549, HeLa or Jurkat cells. Ubiquitously expressed in all tissues.

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant full-length human NME2 protein.

Mouse

Monoclonal

NME2/4160

kappa

Protein A/G chromatography.

200 µg/ml

17 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

C-myc purine-binding transcription factor PUF, EC:2.7.13.3, Histidine protein kinase NDKB, NDK B, NDP kinase B, nm23-H2, NM23B, Nucleoside diphosphate kinase B