Anti-MMP1 Antikörper [3B6] (A279287)

Anti-MMP1 Antibody [3B6]

Mouse monoclonal [3B6] antibody to MMP1.

This antibody recognises human matrix metalloproteinase 1 (MMP-1), also known as interstitial or fibroblast collagenase, a 469 amino acid, in the pro-peptide form, zinc-dependent endopeptidase responsible for degrading the extracellular matrix. MMPs are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. MMP expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. MMP-1 is overexpressed in invasive melanoma, colorectal and esophageal cancers (Langenskiöld et al. 2013). MMP-1 has also been implicated in arthritis and may influence atherosclerotic lesion formation. Additionally, MMP-1 has been implicated in the repair processes of the heart after myocardial infarction. Mouse anti Human MMP-1 has been used successfully for the detection of MMP-1 in gastric cancer by both Western blotting and immunohistochemistry.

WB, IHC-P

Human

Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.

Mouse

Monoclonal

3B6

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Approximately 37 kDa

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human MMP-1 antibody, clone 3B6 recognizes human matrix metalloproteinase 1 (MMP-1), also known as interstitial or fibroblast collagenase, a 469 amino acid, in the pro-peptide form, zinc-dependent endopeptidase responsible for degrading the extracellular matrix. MMPs are also involved in cell proliferation, migration, differentiation and apoptosis (Chen et al. 2013). Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active (Nagase et al. 1992). MMP expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis (Murray et al. 1996). MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma (Robichaud et al. 2011). MMP-1 is overexpressed in invasive melanoma, colorectal and esophageal cancers (Langenskiöld et al. 2013). MMP-1 has also been implicated in arthritis and may influence atherosclerotic lesion formation (Nikkari et al. 1995) . Additionally, MMP-1 has been implicated in the repair processes of the heart after myocardial infarction (Yarbrough et al. 2003).Mouse anti Human MMP-1 has been used successfully for the detection of MMP-1 in gastric cancer by both Western blotting and immunohistochemistry (Murray et al. 1998).

27 kDa interstitial collagenase, CLG, CLGN , collagenase, fibroblast, collagenase, interstitial, Fibroblast collagenase, Interstitial collagenase , Matrix metallopeptidase 1, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metalloprotease 1, Matrix Metalloproteinase 1 , Matrix metalloproteinase-1, MMP 1 , MMP-1, MMP1_HUMAN, OTTHUMP00000045866