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Anti-MiTF Antikörper [PCRP-MITF-1D9] (A277710)

Monoklonal [PCRP-MITF-1D9] Maus Antikörper gegen MiTF für IP, IF, Flow Cytometry und WB.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-MiTF Antibody [PCRP-MITF-1D9]
Beschreibung
Mouse monoclonal [PCRP-MITF-1D9] antibody to MiTF.
Spezifität
MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer and is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP-dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP1 and TRP2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Ser73 (via the MAPK pathway), it associates with co-activators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In MITFdeficient mice there is a complete absence of melanocytes.
Anwendungen
IP, IF, Flow Cytometry, WB
Verdünnungen
IP: 1-2µg / 100-500µg proteins, IF: 1-2 µg/ml, Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml
Reaktivität
Human
Kreuzreaktivität
This antibody is predicted to cross react with Chicken, Mouse, Rat, Xenopus, and Zebrafish.
Immunogen
Recombinant full-length human MiTF protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
PCRP-MITF-1D9
Isotyp
IgG2b
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
52-56 kDa (doublet)
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MiTF Antibody [PCRP-MITF-1D9] - BSA and Azide free (A278298).
Synonyme
bHLHe32, Class E basic helix-loop-helix protein 32, CMM8, Homolog of mouse microphthalmia, Mi, Microphthalmia associated transcription factor, Microphthalmia, mouse, homolog of, Microphthalmia-associated transcription factor, mitfa, MITF_HUMAN, nacre, WS2, WS2A, z3A.1
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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