This antibody recognises C-C motif chemokine-8 (CCL8) also known as HC14, monocyte chemoattractant protein 2, monocytes chemotactic protein 2 and small-inducible cytokine A8. CCL8 is a member of the C-C chemokine subfamily and is an agonist for C-C chemokine receptor type 2 and CCR5. Through these receptors, CCL8 is involved in the immune response by attracting monocytes, T-lymphocytes, natural killer cells, basophils, mast cells and eosinophils. Proteolytic cleavage of CCL8 to CCL8 (6-76) converts the chemokine into a potent inhibitor of C-C chemokine-induced chemotaxis. The purified Mouse anti Human CCL8 antibody, clone E07-8G5 (MCA6266GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL8 antibody, clone E09-8A1 (MCA6267B) as the detection antibody.

Anwendungen

ELISA

Verdünnungen

ELISA: 1 µg/ml

Reaktivität

Human

Immunogen

E. coli derived recombinant human full length CCL8 (Gln24-Pro99).

Wirt

Mouse

Klonalität

Monoclonal

Klon

E07-8G5

Isotyp

IgG2a

Konjugat

Unconjugated

Reinigung

Protein G affinity chromatography of tissue culture supernatant.

Konzentration

1 mg/ml

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Lagerung

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Allgemeine Hinweise

Mouse anti Human CCL8 antibody, clone E07-8G5, recognizes C-C motif chemokine-8 (CCL8) also known as HC14, monocyte chemoattractant protein 2, monocytes chemotactic protein 2 and small-inducible cytokine A8. CCL8 is a member of the C-C chemokine subfamily and is an agonist for C-C chemokine receptor type 2 and CCR5 (Ge et al. 2017). Through these receptors, CCL8 is involved in the immune response by attracting monocytes, T-lymphocytes, natural killer cells, basophils, mast cells and eosinophils (Farmaki et al. 2020). Proteolytic cleavage of CCL8 to CCL8 (6-76) converts the chemokine into a potent inhibitor of C-C chemokine-induced chemotaxis (Proost et al. 1998).The purified Mouse anti Human CCL8 antibody, clone E07-8G5 (MCA6266GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL8 antibody, clone E09-8A1 (MCA6267B) as the detection antibody.

Synonyme

C C motif chemokine 8, CCL 8, Ccl8, CCL8_HUMAN, Chemokine (C C motif) ligand 8, Chemokine ligand 8, HC14, MCP 2, MCP-2, MCP-2(6-76), Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, SCYA10, SCYA8, Small inducible cytokine A8, Small inducible cytokine subfamily A (Cys Cys) member 8, Small-inducible cytokine A8

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.