Anti-Langerin Antibody [LGRN/7428] - BSA and Azide free
Beschreibung
Mouse monoclonal [LGRN/7428] antibody to Langerin.
Spezifität
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Anwendungen
IHC-P
Positivkontrolle
Human skin.
Verdünnungen
IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (around Amino Acids 50-250) of human Langerin protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
LGRN/7428
Isotyp
IgG
Konjugat
Unconjugated
Reinigung
Protein A/G chromatography.
Konzentration
1 mg/ml
Molekulargewicht
48 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
C type lectin domain family 4 member K, C-type lectin domain family 4 member K, CD 207, CD207, CD207 antigen, CD207 antigen, langerin, CD207 molecule, CLC4K_HUMAN, CLEC 4K, CLEC4K, Langerhans cell specific c type lectin, RGD1565913