Anti-Laminin gamma 1 Antikörper [LAMC1/3162] (A277871)

Name: Anti-Laminin gamma 1 Antibody [LAMC1/3162]
Brand: Antibodies.com
SKU: A277871
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [LAMC1/3162] Maus Antikörper gegen Laminin gamma 1 für IHC-P.

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Carrier Free and Preservative Free

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

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Stichworte:

Monospezifischer Antikörper

Produktdetails

Produktname

Anti-Laminin gamma 1 Antibody [LAMC1/3162]

Beschreibung

Mouse monoclonal [LAMC1/3162] antibody to Laminin gamma 1.

Spezifität

Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Murine EHS laminin preparation.

Wirt

Mouse

Klonalität

Monoclonal

Klon

LAMC1/3162

Isotyp

IgG1

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

210 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459).

Synonyme

LAMB2, lamc1, LAMC1_HUMAN, Laminin B2 chain, Laminin subunit gamma-1, Laminin, gamma 1 (formerly LAMB2), Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-7 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, MGC87297, S-LAM gamma, S-laminin subunit gamma

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (2)

Bild Vergrößern

Figure 1: Immunohistochemistry - Anti-Laminin gamma 1 Antibody [LAMC1/3162] (A277871)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue using Anti-Laminin gamma 1 Antibody [LAMC1/3162].

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Figure 2: Anti-Laminin gamma 1 Antibody [LAMC1/3162] (A277871)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Laminin gamma 1 Antibody [LAMC1/3162]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.