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Anti-LAG-3 Antikörper [C9B7W] (A279963)

$800

Monoklonal [C9B7W] Ratte Antikörper gegen LAG-3 für Flow Cytometry und Functional Assays.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-LAG-3 Antibody [C9B7W] - BSA and Azide free
Beschreibung
Rat monoclonal [C9B7W] antibody to LAG-3.
Spezifität
This antibody recognises mouse lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognises an epitope within the D2 domain of CD223. Rat anti Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II.
Anwendungen
Flow Cytometry, Functional Assays
Verdünnungen
Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 106 cells in 100µl.
Reaktivität
Mouse
Immunogen
Murine CD223 Ig fusion protein.
Wirt
Rat
Klonalität
Monoclonal
Klon
C9B7W
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein G affinity chromatography of tissue culture supernatant.
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline.
Lagerung
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Allgemeine Hinweise
Rat anti Mouse CD223 antibody, clone C9B7W recognizes murine lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. Rat anti Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II (Workman et al. 2002).
Synonyme
CD223, CD223 antigen, FDC protein, Lag3, LAG3_HUMAN, Lymphocyte activating 3, Lymphocyte Activation Gene 3, Lymphocyte activation gene 3 protein, Protein FDC
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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