Anti-Kappa Light Chain Antikörper [KLC1278] (A248984)

Anti-Kappa Light Chain Antibody [KLC1278]

Mouse monoclonal [KLC1278] antibody to Kappa Light Chain.

This antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant human Ig kappa chain.

Mouse

Monoclonal

KLC1278

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

~22.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Kappa Light Chain Antibody [KLC1278] - BSA and Azide free (A252164).

HCAK 1, HCAK1, Ig kappa chain C region, IGKC, IGKCD, Immunoglobulin InV, Immunoglobulin kappa constant, Immunoglobulin kappa constant region, Immunoglobulin kappa light chain, Immunoglobulin kappa light chain constant region, Immunoglobulin KM, Kappa 1 immunoglobulin light chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809