This antibody recognises CD339, otherwise known as Jagged1, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.In humans, mutations in the JAG1 gene are responsible for the autosomal dominant multisystem disorder Alagille syndrome 1 (ALGS1)
Anwendungen
Flow Cytometry, IHC-Fr
Verdünnungen
Use 10µl of the suggested working dilution to label 1x106 cells in 100µl.
Reaktivität
Mouse, Rat
Immunogen
CHO cells expressing Jagged1.
Wirt
Hamster
Klonalität
Monoclonal
Klon
HMJ1-29
Isotyp
IgG
Konjugat
Unconjugated
Reinigung
Protein G affinity chromatography.
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Hamster anti Mouse CD339 antibody, clone HMJ1-29 specifically recognizes CD339, otherwise known as Jagged1, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.In humans, mutations in the JAG1 gene are responsible for the autosomal dominant multisystem disorder Alagille syndrome 1 (ALGS1)
Synonyme
AGS, AHD, AWS, CD 339, CD339, CD339 antigen, Headturner, hJ1, Htu, Jag 1, Jag1, JAG1_HUMAN, Jagged 1, Jagged1 (Alagille syndrome), JAGL1, MGC104644, OTTHUMP00000030278, Protein jagged-1, Ser 1, Ser1, Serrate 1, Slalom