Rabbit polyclonal antibody to IRS1 (phospho Ser312).
Spezifität
This antibody recognises insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling.
Anwendungen
WB
Verdünnungen
WB: 1:500 - 1:2,000
Reaktivität
Human, Mouse, Rat
Immunogen
Phospho-specific peptide corresponding to residues surrounding Ser312 of human IRS1.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat
Unconjugated
Konzentration
Lot Specific
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Lagerung
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Allgemeine Hinweise
Rabbit anti IRS1 (pSer312) antibody recognizes insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling (Zhang et al. 2008).
