This antibody recognises human interferon regulatory factor 7 (IRF7), a ~54 kDa transcriptional activator of type I interferons (IFNalpha/beta) in response to local and systemic viral infection. IRF7 is mostly expressed by plasmacytoid dendritic cells (pDC), which differentiate in response to IFNs and virus infection. This then stabilizes the IRF7 protein, in turn leading to increased IFN production.Multiple IRF7 transcript variants have been identified, although their individual functions have not yet been established.
Anwendungen
WB
Verdünnungen
WB: 0.5 - 1 µg/ml
Reaktivität
Human
Immunogen
A peptide corresponding to 14 amino acids near the centre of human IRF7.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat
Unconjugated
Konzentration
1 mg/ml
Molekulargewicht
Approximately 51 kDa in 293 whole cell lysate.
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Rabbit anti Human IRF7 antibody detects human interferon regulatory factor 7 (IRF7), a ~54 kDa transcriptional activator of type I interferons (IFNalpha/beta) in response to local and systemic viral infection. IRF7 is mostly expressed by plasmacytoid dendritic cells (pDC), which differentiate in response to IFNs and virus infection. This then stabilizes the IRF7 protein, in turn leading to increased IFN production.Multiple IRF7 transcript variants have been identified, although their individual functions have not yet been established.
