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Anti-IRAK4 Antikörper (A283176)

$420

Polyklonal Kaninchen Antikörper gegen IRAK4 für WB und IHC-Fr.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-IRAK4 Antibody
Beschreibung
Rabbit polyclonal antibody to IRAK4.
Spezifität
This antibody recognises an epitope within the C-terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 is a 460 amino acid ~50 kDa, cytoplasmic protein and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.Two isoforms of IRAK4 produced by alternative splicing are predicted, Rabbit anti Human IRAK4 (C-terminal) antibody is expected to recognize both isoforms which differ by an N-terminal deletion.Mutations in the IRAK4 gene can lead to the development of Recurrent isolated invasive pneumococcal disease 1 (IPD1) characterized by multiple episodes of IPD occurring at least one month apart. IRAK4 mutation can also lead to the development of IRAK4 deficiency (IRAK4D) demonstrating extracellular pyogenic bacterial and fungal infections in otherwize healthy children.
Anwendungen
WB, IHC-Fr
Verdünnungen
IHC-Fr: 10 µg/ml, WB: 1 - 2 µg/ml
Reaktivität
Human
Immunogen
A peptide corresponding to amino acids at the C-terminus of human IRAK4.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat

Unconjugated

Konzentration
1 mg/ml
Molekulargewicht
Approximately 50 kDa in HeLa cell lysates.
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Rabbit anti Human IRAK4 (C-Terminal) antibody detects an epitope within the C-Terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 is a 460 amino acid ~50 kDa, cytoplasmic protein and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.Two isoforms of IRAK4 produced by alternative splicing are predicted, Rabbit anti Human IRAK4 (C-Terminal) antibody is expected to recognize both isoforms which differ by an N-terminal deletion.Mutations in the IRAK4 gene can lead to the development of Recurrent isolated invasive pneumococcal disease 1 (IPD1) characterized by multiple episodes of IPD occurring at least one month apart (Ku et al. 2007). IRAK4 mutation can also lead to the development of IRAK4 deficiency (IRAK4D) demonstrating extracellular pyogenic bacterial and fungal infections in otherwize healthy children (Picard et al. 2003).
Synonyme
IL-1 receptor-associated kinase 4, Interleukin 1 receptor associated kinase 4 mutant form 1, Interleukin-1 receptor-associated kinase 4, Interleukin1 receptor associated kinase 4, IPD1, IRAK 4, IRAK-4, IRAK4 mutated form 1, IRAK4_HUMAN, LOC 51135, NY REN 64, NY REN 64 antigen, NY-REN-64, REN64, Renal carcinoma antigen NY-REN-64
Isotyp-Kontrollantikörper
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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