Anti-Interferon alpha 1 Antibody [IFNA/6689] (A277653)

Anti-Interferon alpha 1 Antibody [IFNA/6689]

Mouse monoclonal [IFNA/6689] antibody to Interferon alpha 1.

This antibody is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.Produced by macrophages, IFN-alphas have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant full-length human IFNA1 protein.

Mouse

Monoclonal

IFNA/6689

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

16-27 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Interferon alpha 1 Antibody [IFNA/6689] - BSA and Azide free (A278241).

IFL, IFN, IFN alpha, IFN alpha 1/13, IFN alpha 1b, IFN alphaD, IFN-alpha-1/13, IFNA1, IFNA13, IFNA1_HUMAN, IFNA@, Interferon alpha, Interferon alpha-1/13, Interferon alpha-D, Interferon alpha1, Interferon, alpha 13, LeIF D