Spezifität
This antibody recognises rabbit interleukin-17A (IL-17A), a 35 kDa disulfide-linked homodimer consisting of two 153 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217).IL-17, originally thought to have been produced primarily by activated CD4+ T cells, appears to have a range of cellular origins and induces a variety of target cells to secrete inflammatory cytokines, including IL-1β, IL-6, TNFα, IFNγ and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists.