This antibody recognises human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II.IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumour types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Anwendungen

WB, ELISA

Verdünnungen

ELISA: 0.5 - 2 µg/ml, WB: 0.1 - 0.2 µg/ml

Reaktivität

Human

Immunogen

Recombinant human IGFBP-7.

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Konzentration

1 mg/ml after reconstitution.

Produktform

Lyophilized

Rekonstitution

Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended.

Formulierung

Supplied in Phosphate Buffered Saline.

Lagerung

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Allgemeine Hinweise

Rabbit anti Human IGFBP-7 antibody recognizes human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II.IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumour types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Synonyme

AGM, Angiomodulin, FSTL2, IBP-7, IBP7, IBP7_HUMAN, IGF binding protein 7, IGF-binding protein 7, IGFBP rP1, IGFBP-7, IGFBP-rP1, IGFBPRP1, Insulin like growth factor binding protein 7, Insulin-like growth factor-binding protein 7, MAC25, MAC25 protein, PGI2 stimulating factor, PGI2-stimulating factor, Prostacyclin stimulating factor, Prostacyclin-stimulating factor, PSF, RAMSVPS, TAF, Tumor-derived adhesion factor

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.