Recombinant Anti-HLA Class II DRB1 Antibody [HLA-DRB/7058R] (A315088)

Anti-HLA Class II DRB1 Antibody [HLA-DRB/7058R]

Recombinant rabbit monoclonal [HLA-DRB/7058R] antibody to HLA Class II DRB1.

This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. s respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Human lymphoid tissue.

IHC: 1-2 µg/ml

Human

Recombinant full-length human HLA-DRB1 protein.

Rabbit

Monoclonal

HLA-DRB/7058R

kappa

Protein A/G chromatography.

200 µg/ml

28 kDa (beta chain)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

HLA class II histocompatibility antigen, DRB1 beta chain, HLA-DRB1, Human leukocyte antigen DRB1