Anti-Haptoglobin Antikörper [HP/3835] (A277646)

Name: Anti-Haptoglobin Antibody [HP/3835]
Brand: Antibodies.com
SKU: A277646
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [HP/3835] Maus Antikörper gegen Haptoglobin für IHC-P.

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Carrier Free and Preservative Free

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

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Telefon

+1 (314) 370-6046

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Monospezifischer Antikörper

Produktdetails

Produktname

Anti-Haptoglobin Antibody [HP/3835]

Beschreibung

Mouse monoclonal [HP/3835] antibody to Haptoglobin.

Spezifität

Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes, thereby inhibiting its oxidative activity. During this process, Haptoglobin sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis, Haptoglobin consists of two a and two b chains, connected by disulfide bridges. In human, Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1, Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia, the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin, lung and kidney.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 100-250, of human Haptoglobin. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

HP/3835

Isotyp

IgG1

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

15-18 kDa / 45 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Haptoglobin Antibody [HP/3835] - BSA and Azide free (A278234).

Synonyme

binding peptide, BP, haptoglobin alpha 1S beta, haptoglobin alpha 2FS beta, Haptoglobin alpha chain, haptoglobin alpha polypeptide, Haptoglobin alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, haptoglobin beta polypeptide, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HP2ALPHA2, HPA1S, HPT, HPT_HUMAN, MGC111141, Zonulin

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (4)

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Figure 1: Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] (A277646)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver tissue using Anti-Haptoglobin Antibody [HP/3835] at 2µg/ml.

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Figure 2: Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] (A277646)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver tissue using Anti-Haptoglobin Antibody [HP/3835] at 2µg/ml.

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Figure 3: SDS-PAGE - Anti-Haptoglobin Antibody [HP/3835] (A277646)

SDS-PAGE analysis of Anti-Haptoglobin Antibody [HP/3835] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-Haptoglobin Antibody [HP/3835] (A277646)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Haptoglobin Antibody [HP/3835]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.