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Anti-Haptoglobin Antikörper [HP/3834] (A316440)

$765

Monoklonal [HP/3834] Maus Antikörper gegen Haptoglobin für WB und IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-Haptoglobin Antibody [HP/3834] - BSA and Azide free
Beschreibung
Mouse monoclonal [HP/3834] antibody to Haptoglobin.
Spezifität
Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes, thereby inhibiting its oxidative activity. During this process, Haptoglobin sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis, Haptoglobin consists of two a and two b chains, connected by disulfide bridges. In human, Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1, Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia, the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin, lung and kidney.
Anwendungen
WB, IHC-P
Positivkontrolle
Human liver.
Verdünnungen
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (around Amino Acids 100-250) of human HP protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
HP/3834
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
1 mg/ml
Molekulargewicht
15-18 kDa / 45 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
binding peptide, BP, haptoglobin alpha 1S beta, haptoglobin alpha 2FS beta, Haptoglobin alpha chain, haptoglobin alpha polypeptide, Haptoglobin alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, haptoglobin beta polypeptide, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HP2ALPHA2, HPA1S, HPT, HPT_HUMAN, MGC111141, Zonulin
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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