This antibody recognises brain glycogen phosphorylase, a regulatory enzyme which catalyses the rate-determining step in glycogen degradation. Mammalian glycogen phosphorylase is found as three major isozymes including muscle (GPMM), liver (GPLL), and brain (GPBB), which can be distinguished by their structural and functional properties as well as by the tissues in which they are expressed. GPBB is thought to function in the release of emergency glucose during stress, and in embryogenesis where it is the predominant isozyme. GPBB is also expressed in the early stages of gastric and colorectal cancers.
Anwendungen
IHC-P
Verdünnungen
IHC-P 1: 10 µg/ml
Reaktivität
Human
Immunogen
Synthetic peptide corresponding to the internal domain of human brain glycogen phosphorylase, conjugated to Keyhole Limpet Haemocyanin.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat
Unconjugated
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Rabbit anti Human glycogen phosphorylase BB antibody detects brain glycogen phosphorylase, a regulatory enzyme which catalyses the rate-determining step in glycogen degradation. Mammalian glycogen phosphorylase is found as three major isozymes including muscle (GPMM), liver (GPLL), and brain (GPBB), which can be distinguished by their structural and functional properties as well as by the tissues in which they are expressed. GPBB is thought to function in the release of emergency glucose during stress, and in embryogenesis where it is the predominant isozyme. GPBB is also expressed in the early stages of gastric and colorectal cancers.
