Anti-GnRHR Antibody [A9E4] - BSA and Azide free (A251925)

Anti-GnRHR Antibody [A9E4] - BSA and Azide free

Mouse monoclonal [A9E4] antibody to GnRHR.

This antibody recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

Human

This antibody is predicted to cross react with Porcine and Rabbit.

Synthetic peptide corresponding to amino acids 1-29 of human GnRH receptor.

MANSASPEQNQHCSAINNSIPLMQGNLPY

Mouse

Monoclonal

A9E4

kappa

Protein A/G chromatography.

1 mg/ml

54-60 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GnRH receptor, GnRH-R, Gonadotropin-releasing hormone receptor, GRHR