Mouse monoclonal [GLUL/6601] antibody to Glutamine Synthetase.
Spezifität
Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
Anwendungen
WB, IHC-P
Positivkontrolle
Human brain, stomach or thyroid. A-431 or Y79 cells.
Verdünnungen
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reaktivität
Human, Horse, Canine, Feline
Immunogen
Recombinant fragment (around Amino Acids 50-250) of human GLUL protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
GLUL/6601
Isotyp
IgG2b
Leichte Ketten
kappa
Konjugat
Unconjugated
Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
42 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.