GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. Cross-linking experiments have shown that GFRP is usually expressed as a homodimer or pentamer.
Anwendungen
WB, IHC-P
Positivkontrolle
Human liver or intestine.
Verdünnungen
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment human GCHFR protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
GCHFR/7734
Isotyp
IgG2
Leichte Ketten
kappa
Konjugat
Unconjugated
Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
63 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
