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Anti-Gbx2 Antikörper [GBX2/7235] (A316382)

$765

Monoklonal [GBX2/7235] Maus Antikörper gegen Gbx2 für IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-Gbx2 Antibody [GBX2/7235] - BSA and Azide free
Beschreibung
Mouse monoclonal [GBX2/7235] antibody to Gbx2.
Spezifität
The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis; GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.
Anwendungen
IHC-P
Positivkontrolle
Human placenta or brain.
Verdünnungen
IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (around Amino Acids 150-350) of human GBX2 protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
GBX2/7235
Isotyp
IgG2
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
1 mg/ml
Molekulargewicht
37 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
Gastrulation and brain-specific homeobox protein 2, Gastrulation brain homeo box 2, Gastrulation brain homeobox 2, GBX2_HUMAN, Homeobox protein GBX 2, Homeobox protein GBX-2, Homeobox protein GBX2, Homeobox protein STRA7, Mmoxa
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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