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Anti-GBP1 Antikörper [GBP1/7617] (A316380)

$765

Monoklonal [GBP1/7617] Maus Antikörper gegen GBP1 für IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-GBP1 Antibody [GBP1/7617] - BSA and Azide free
Beschreibung
Mouse monoclonal [GBP1/7617] antibody to GBP1.
Spezifität
GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.
Anwendungen
IHC-P
Positivkontrolle
Human colon or cerebral cortex tissue.
Verdünnungen
IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (around Amino Acids 400-592) of human GBP1 protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
GBP1/7617
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
1 mg/ml
Molekulargewicht
67 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
GBP 1, GBP-1, GBP1_HUMAN, GTP binding protein 1, GTP-binding protein 1, Guanine nucleotide binding protein 1, Guanine nucleotide-binding protein 1, Guanylate binding protein 1, Guanylate binding protein 1 interferon inducible, Guanylate binding protein 1 interferon inducible 67kDa, HuGBP 1, HuGBP-1, HuGBP1, Interferon induced guanylate binding protein 1, Interferon-induced guanylate-binding protein 1, OTTHUMP00000012352
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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