+1 (314) 370-6046 oderKontakt

Anti-GAD67 Antikörper [GAD1/2391] (A248674)

Monoklonal [GAD1/2391] Maus Antikörper gegen GAD67 für ELISA, WB und IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-GAD67 Antibody [GAD1/2391]
Beschreibung
Mouse monoclonal [GAD1/2391] antibody to GAD67.
Spezifität
This antibody recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
Anwendungen
ELISA, WB, IHC-P
Verdünnungen
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment, around amino acids 72-135, of human GAD67 protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
GAD1/2391
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
67 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-GAD67 Antibody [GAD1/2391] - BSA and Azide free (A251856).
Synonyme
67 kDa glutamic acid decarboxylase, CPSQ1, DCE1, DCE1_HUMAN, EC 4.1.1.15, FLJ45882, GAD, GAD 67, GAD-67, GAD1, Glutamate decarboxylase 1, Glutamate decarboxylase 1 (brain, 67kDa), Glutamate decarboxylase 1 brain 67kD, Glutamate decarboxylase 1 brain 67kDa, Glutamate decarboxylase 67 kDa isoform, Glutamate decarboxylase, brain, 67-KD, OTTHUMP00000041055, SCP
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Alternative Produkte zum Anti-GAD67 Antikörper [GAD1/2391] (A248674)

Oben