Anti-FOXB1 Antibody [PCRP-FOXB1-1B7] - BSA and Azide free
Beschreibung
Mouse monoclonal [PCRP-FOXB1-1B7] antibody to FOXB1.
Spezifität
The Forkhead-box (FOX) genes comprise a superfamily of at least 43 members that encode proteins which are involved in transcriptional regulation and may be associated with the pathogenesis of various cancers. FOXB1 (forkhead box B1), also known as FKH5 or HFKH-5, and FOXB2 (forkhead box B2) are members of the FOX family and each contain one forkhead DNA-binding domain. Both FOXB1 and FOXB2 localize to the nucleus where they are thought to function as transcription factors that can bind to DNA via their forkhead domains. In mice, defects in the gene encoding FOXB1 are associated with retarded development of the central nervous system (CNS), suggesting that FOXB1 may play a role in CNS organization and function.
Flow cytometric analysis of PFA-fixed HeLa cells using Anti-FOXB1 Antibody [PCRP-FOXB1-1B7] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
SDS-PAGE analysis of Anti-FOXB1 Antibody [PCRP-FOXB1-1B7] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Immunofluorescent analysis of PFA-fixed HeLa cells stained with Anti-FOXB1 Antibody [PCRP-FOXB1-1B7] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
Analysis of protein array containing more than 19,000 full-length human proteins using Anti-FOXB1 Antibody [PCRP-FOXB1-1B7]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Alternative Produkte zum Anti-FOXB1 Antikörper [PCRP-FOXB1-1B7] (A278218)