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Anti-Fibroblast Activation Protein alpha Antikörper [FAP/4853] (A277595)

Monoklonal [FAP/4853] Maus Antikörper gegen Fibroblast Activation Protein alpha für IHC-P.

Alternative Formats and ConjugatesAlternative Formats

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Empfohlene Produkte für Anti-Fibroblast Activation Protein alpha Antikörper

Produktname
Anti-Fibroblast Activation Protein alpha Antibody [FAP/4853]
Beschreibung
Mouse monoclonal [FAP/4853] antibody to Fibroblast Activation Protein alpha.
Spezifität
FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.
Anwendungen
IHC-P
Verdünnungen
IHC-P: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment, around amino acids 1-200, of human Fibroblast Activation Protein alpha. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
FAP/4853
Isotyp
IgG2c
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
88 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4853] - BSA and Azide free (A278183).
Synonyme
170 kDa melanoma membrane bound gelatinase, 170 kDa melanoma membrane-bound gelatinase, DPPIV, FAP, FAPA, Fibroblast activation protein, alpha, Integral membrane serine protease, Seprase, SEPR_HUMAN
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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