Anti-Fascin Antikörper [FSCN1/7207] (A314951)

Anti-Fascin Antibody [FSCN1/7207]

Mouse monoclonal [FSCN1/7207] antibody to Fascin.

Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

IHC-P

HeLa, MCF-7, PC-3 or BEWO cells. Hodgkin s lymphoma, ovarian or testicular carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 350-400) of human FSCN1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

FSCN1/7207

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

55 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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