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Anti-Factor VIII Antikörper [RFF-VIIIC/10] (A281665)

$480

Monoklonal [RFF-VIIIC/10] Maus Antikörper gegen Factor VIII für ELISA und RIA.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-Factor VIII Antibody [RFF-VIIIC/10]
Beschreibung
Mouse monoclonal [RFF-VIIIC/10] antibody to Factor VIII.
Spezifität
This antibody recognises human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A (HEMA), a disorder characterised by the body’s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. recognises an epitope within the non-functional, middle domain of full-length Factor VIII.
Anwendungen
ELISA, RIA
Reaktivität
Human
Immunogen
Affinity purified human Factor VIII.
Wirt
Mouse
Klonalität
Monoclonal
Klon
RFF-VIIIC/10
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein G affinity chromatography of tissue culture supernatant.
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/10 recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A (HEMA), a disorder characterised by the body’s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/10 recognizes an epitope within the non-functional, middle domain of full-length Factor VIII.
Synonyme
AHF, Antihemophilic factor, Coagulation factor VIII, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, DXS1253E, F8, F8b, F8c, FA8_HUMAN, factor VIII F8B, Factor VIIIa light chain, FactorVIII, FVIII, Hema, Hemophilia A, Hemophilia, classic, OTTHUMP00000061446, OTTHUMP00000196174, Procoagulant component
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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