Anti-Eotaxin 2 Antikörper [C05-2B5] (A279935)

Anti-Eotaxin 2 Antibody [C05-2B5]

Mouse monoclonal [C05-2B5] antibody to Eotaxin 2.

This antibody recognises C-C motif chemokine 24, also known as Eotaxin-2, CK-beta-6, and MPIF-2. CCL24 is a chemokine which is induced in macophages and promotes recruitment and activation of immune cells including eosinophils, basophils, and Th2 cells by interacting with the CCR3 receptor. Therefore, CCL24 expression increases during inflammatory disease and allergic reaction, and CCL24 has been shown to perpetuate allergic reaction. CCL24 is involved with proinflammatory and profibrotic reactions, particularly fibrosis of the skin and lungs. Furthermore, CCL24 plays a role in intrahepatic fibrosis and liver damage. Elevated CCL24 has been associated with primary colorectal and liver metastatic tumors. The purified Mouse anti Human CCL24 antibody, clone C05-2B5 (MCA6182GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL24 antibody, clone B01-5E2 (MCA6183B) as the detection antibody.

ELISA

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL24 (Val27-Ala104).

Mouse

Monoclonal

C05-2B5

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CCL24 antibody, clone C05-2B5recognizes C-C motif chemokine 24, also known as Eotaxin-2, CK-beta-6, and MPIF-2. CCL24 is a chemokine which is induced in macophages and promotes recruitment and activation of immune cells including eosinophils, basophils, and Th2 cells by interacting with the CCR3 receptor. Therefore, CCL24 expression increases during inflammatory disease and allergic reaction, and CCL24 has been shown to perpetuate allergic reaction (Cho et al. 2016). CCL24 is involved with proinflammatory and profibrotic reactions, particularly fibrosis of the skin and lungs (Mor et al. 2019). Furthermore, CCL24 plays a role in intrahepatic fibrosis and liver damage (Segal-Salto et al. 2020). Elevated CCL24 has been associated with primary colorectal and liver metastatic tumors (Cheng et al. 2017).The purified Mouse anti Human CCL24 antibody, clone C05-2B5 (MCA6182GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL24 antibody, clone B01-5E2 (MCA6183B) as the detection antibody.

C C motif chemokine 24, C-C motif chemokine 24, CCL24, CCL24_HUMAN, Chemokine (C C motif) ligand 24, Chemokine CC Motif Ligand 2, Chemokine CC Motif Ligand 24, CK beta 6, CK-beta-6, Ckb 6, Ckb6, Eosinophil chemotactic protein 2, Eotaxin 2 like protein, Eotaxin-2, MPIF 2, MPIF-2, MPIF2 , Myeloid progenitor inhibitory factor 2 , OTTHUMP00000210225, SCYA24, Small inducible cytokine A24, Small inducible cytokine subfamily A (Cys Cys) member 24 , Small inducible cytokine subfamily A (Cys-Cys) member 24, Small-inducible cytokine A24